Search results for "Specialized pro-resolving mediators"

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An SPM-Enriched Marine Oil Supplement Shifted Microglia Polarization toward M2, Ameliorating Retinal Degeneration in rd10 Mice

2022

Retinitis pigmentosa (RP) is the most common inherited retinal dystrophy causing progressive vision loss. It is accompanied by chronic and sustained inflammation, including M1 microglia activation. This study evaluated the effect of an essential fatty acid (EFA) supplement containing specialized pro-resolving mediators (SPMs), on retinal degeneration and microglia activation in rd10 mice, a model of RP, as well as on LPS-stimulated BV2 cells. The EFA supplement was orally administered to mice from postnatal day (P)9 to P18. At P18, the electrical activity of the retina was examined by electroretinography (ERG) and innate behavior in response to light were measured. Retinal degeneration was …

InflammationPhysiologyInherited retinal dystrophiesClinical BiochemistryCell BiologyBiochemistrySpecialized pro-resolving mediatorsMedicaments Assaigs clínicsRetinitis pigmentosainherited retinal dystrophies; retinitis pigmentosa; inflammation; microglia; specialized pro-resolving mediators; oxidative stressOxidative stressUlls Malalties i defectesMicrogliaMolecular Biology

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